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Welcome to the Sham Research Group in the Center for Drug Design at the University of Minnesota. Many of the diseases today can be treated by the inhibition of protein targets that play an essential role in the life cycle for a virus, bacteria or cancer cells. My research group is interested in developing consistent and accurate computational approaches to study the energy, structure and function relationships of biomolecular systems and their applications to therapeutic discovery. Our goal is to understand the molecular recognition process which plays a critical role in the cellular signaling processes and enzyme catalysis. Particularly, We are focused in studying the protein-protein and protein-substrate interactions. Ability to quantify analytically these interactions will provide us with an insight on how these therapeutic targets selectively bind as well as a rational basis to structure based drug design. In collaboration with other members of CDD, we are currently working on protein targets that are important for the treatment of AIDS, tuberculosis, and cancer.

Contact
Yuk Sham
Assistant Professor and Assistant Director
Graduate Faculty, Biomedical Informatics and Computational Biology Program
Office: 7-220 Phillips Wangensteen
Phone: 612-625-8255
Fax: 612-625-8154
E-mail: shamx002@umn.edu